A Rationalized Description on Study of Intestinal Barrier, Drug Permeability and Permeation Enhancers
نویسندگان
چکیده
Per oral delivery of hydrophilic drugs is one of the most challenges in biopharmaceutical research. Hydrophilic drugs show low bioavailability following oral administration because of their poor intestinal permeation. In the last few years great interest has focused on search of different intestinal permeation enhancers for the oral delivery of BCS class iii drugs, small polar molecules, vaccines, hormones, peptides and proteins, which are well suitable for the delivery of the above products to give enhanced bioavailability by increasing intestinal permeability. This review sets out to discuss about anatomy and physiology of the intestinal barrier, drug absorption from intestinal tract, mechanism of intestinal drug permeability, detail information about intestinal permeation enhancers and its mechanism of action, invitro methods for studying drug permeability, advantages and applications of intestinal permeation enhancers.
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